Familial multiple lipomatosis is a hereditary syndrome of uncertain prevalence. Multiple discrete, encapsulated lipomas are found on the trunk and extremities, with relative sparing of the head and shoulders. The number of tumors in any one patient may vary considerably. Although tumors usually range in size from a few millimeters to 6 cm in diameter, lipomas as large as 25 cm have been reported. . Spontaneous regression and malignant degeneration are rare. The disease is not associated with any abnormalities in lipid metabolism .
From case reports, most authors have inferred an autosomal dominant mode of inheritance, although men are affected twice as commonly as women . However, many of these reports are incomplete, as oftentimes the disease does not manifest until after age 30.
Although multiple lipomatosis was first reported in 1846 by Brodie, familial multiple lipomatosis was not reported until 1891 when Blashko described a man, his brother, and several of his children with a similar condition. In 1993 the genetic defect was isolated to chromosome 12q15, which encodes the high-mobility-group protein isoform I-C (HMGIC) . It is now believed that this disorder results from a translocation involving HMGIC on chromosome 12 and the lipoma preferred partner gene (LLP) on chromosome 3 . Although this condition is benign, many patients concerned with cosmesis seek removal of individual tumors. Treatment can include simple excision, endoscopic removal, or liposuction .