Tune in. Never miss
an important update!
Your Name
Your Email
Lipoma Board

In Search of Best Lipoma Treatment And Cure

What is Lipoma Board? A forum and community offering information, alternative treatments, resources and support concerning lipomas, lipomatosis and other related conditions. Surgery shouldn't be the only option! Lipomas are fatty tumors under the skin. Read more >>

All times are UTC [ DST ]

Triphala



Post new topic Reply to topic  [ 1 post ] 
  Print view

 ATX-101 lipoma injection
Author Message
PostPosted: 3/1/11 Tuesday, 3:20 pm 
Site Admin
Offline

Joined:Thu Jan 27, 2011 12:43 pm
Posts:9
A research center in California, Kythera Biopharmaceuticals, has been developing their new product ATX-101 (fat reduction drug) for years now. It is currently in phase three (the phase before the market) but is still suspected to be in trial phase for a some years.

They are actually suggesting that Deoxycholite alone is helping the lipomas to shrink and that Phosphatidylcholine is actually inhibiting the cell death. Source: http://www.kytherabiopharma.com/pdf/200 ... n_vivo.pdf [pdf]

One hundred twenty-nine subjects were randomized in a double-blind, placebo-controlled, dose-ranging study conducted across 10 dermatology and plastic surgery centers in the United States (ATX-101-09-15). Subjects received one of two dosing regimens of ATX-101 (1 mg/cm2 or 2 mg/cm2) or placebo, administered monthly for up to 5 months into the submental area. Clinician assessments were performed at all treatment visits and 4 and 12 weeks after the last treatment visit (week 24 and week 32, respectively). Subject self-assessments and MRI assessments were performed at baseline, treatment visit 5 (week 16) and 12 weeks after the last treatment visit (week 32).

In this study, the 2 mg/cm2 proved to be the more efficacious dose and yielded a statistically significant reduction of unwanted submental fat compared to placebo as measured by physician assessment (p=0.001 and p=0.003, week 24 and week 32, respectively). Evidence of improvement was observed at 1 mg/cm2, indicating that a dose response exists between the two ATX-101 regimens. Physician assessment was performed using a validated, 5-point Clinician-Reported Submental Fat Rating Scale (CR-SMFRS). In addition, the 2 mg/cm2 dose group yielded a statistically significant reduction of submental fat as measured by subject assessment (p<0.05, week 16 and week 32). Subjects assessed submental fat using a 5-point Patient Reported Outcomes (PRO) tool, the Patient-Reported Submental Fat Rating Scale (PR-SMFRS).


“The results from this study are exciting and indicate the potential of ATX-101 as an effective and well-characterized treatment for the aesthetic reduction of small volumes of fat,” said Joel Schlessinger, MD, a board-certified dermatologist and cosmetic surgeon in private practice in Omaha, Nebraska and an investigator in this study. “There are currently no FDA-approved non-surgical treatment modalities for the reduction of fat under the chin. ATX-101 may represent a breakthrough for patients who are seeking a minimally-invasive treatment option for the reduction of unwanted localized submental fat.”
Source: http://www.kytherabiopharma.com/newsroom/



Top
 Profile Send private message  
Reply with quote  

Display posts from previous:  Sort by  
Post new topic Reply to topic  [ 1 post ] 

All times are UTC [ DST ]


  Similar topics


  Who is online

Users browsing this forum: No registered users and 1 guest


You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot post attachments in this forum

Search for:
Jump to:  
injectable collagenase multiple lipoma treatment icd 9 lipoma lipomatous tissue lipoma icd 9 submental lipomatosis what is lipomas what are lipomas lipoma disease lipoma photos lipomas photos what are lipomas definition lipoma multiple symmetric lipomatosis lipoma pain lipoma disease bariena lunulina what is lipoma familial multiple lipomatosis familial lipomatosis benign symmetric lipomatosis familial multiple lipomatosis familial lipomatosis hereditary multiple lipomatosis painful lipoma painful lipomas encapsulated lipoma multiple lipomatosis definition of familial superficial subcutaneous lipoma lipomatosis definition lipoma painful what causes lipoma lipoma treatments multiple lipomatosis lipomatosis definition madelung syndrome collagenase injection lipoma treatment options what is a lipoma benign lipoma benign lipoma pictures what causes lipomas lipoma surgery cost definition of lipoma xiaflex treatment lipomas painful low moral define lipoma lipoma buttock multiple lipoma multiple lipomas lipoma cure