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In Search of Best Lipoma Treatment And Cure

What is Lipoma Board? A forum and community offering information, alternative treatments, resources and support concerning lipomas, lipomatosis and other related conditions. Surgery shouldn't be the only option! Lipomas are fatty tumors under the skin. Read more >>

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 Xiaflex lipoma treatment
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PostPosted: 4/5/11 Tuesday, 6:55 pm 
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Joined:Tue Mar 29, 2011 8:01 am
Location: Finland
Number of lipomas: 61-100
Don't know much about this, but I stumbled upon this article which mentions lipoma. I think this is the same drug mentioned in here: http://www.biospecifics.com/pipeline/

A drug called Xiaflex is in the Phase III in the drug trials by Auxilium Pharmaceuticals, Inc. At least according to this article it's still in the trials: http://www.zacks.com/stock/news/41563/X ... II+Program

Label expansion could help Xiaflex sales cross $1 billion. Meanwhile, Auxilium Pharma is looking to conduct additional studies with Xiaflex for frozen shoulder syndrome. Frozen shoulder syndrome is a disorder of diminished shoulder motion and almost 3% of people, especially women, develop this problem over their lifetime. Other indications for which Xiaflex could be developed include cellulite and lipoma.

https://www.xiaflex.com site mentions that Xiaflex is a compound of collagenase and this site http://www.biospecifics.com/pipeline tells that Xiaflex is currently approved for the treatment of Dupuytren's Contracture (a fixed flexion contracture of the hand where the fingers bend towards the palm and cannot be fully extended (straightened)).

Sadly it also mentions that the trials are in the very early phase for other indications, such as lipoma treatment:

In addition to our lead product candidates, collagenase has been tested in the following clinical indications:


Lipomas are benign fatty tumors that occur as bulges under the skin. An open-label Phase I clinical trial has been completed for treatment of lipomas utilizing a single injection of collagenase. This trial was designed based on observations made during preclinical studies that a collagenase injection decreased the size of fat pads in animals. Favorable initial results, demonstrating that 10 out of 12 patients had a 50-90% reduction in the size of the lipoma, were presented at a meeting of the American Society of Plastic Surgeons.
There is a strong need for a minimally invasive approach for humans and canines. There are 575,000 U.S. patients annually who don’t show improvement without surgical intervention. Lipomas are found in 1.7 million dogs in the U.S. annually. As with humans, surgery is the most frequent option but it is risky, especially for older dogs, due to the need for general anesthesia.

It could still take years before this drug is approved to treat lipomas. At least the ATX-101 of Kythera Pharmaceuticals has been in the pipeline for quite some time. I first encountered it in 2007 and it's currently starting the phase III.

Again, collagenase injection will not cure lipomas but will most likely shrink the existing tumors and help cosmetically.

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 Re: Xiaflex lipoma treatment
PostPosted: 11/16/13 Saturday, 4:51 pm 

Joined:Fri Nov 15, 2013 8:23 pm
Anyone with recent success in Xiaflex or Collagenase injections?

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