Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

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Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by matt » Thu Dec 08, 2011 9:58 am

I came across this interesting article by a retired medical doctor Cantwell about the connection of the bacteria and cancer. Dr Cantwell is the author of The Cancer Microbe.

He suggests in his article that we may eventually accept bacterial causes for cancer since the medical world has also before misdiagnosed some bacterial diseases:
...when a new and deadly lung disease broke out among legionnaires in Philadelphia in July 1976, two hundred twenty-two people became ill and thirty-four died. The cause of the lung disease remained a medical mystery for over five months. Bacterial infection was ruled out when all tests were reported as negative. Fortunately, one astute and careful microbiologist finally discovered bacteria. Joe McDade at the Leprosy Branch of the CDC, was able to detect “unusual bacteria” in guinea pigs experimentally infected with lung tissue from the dead legionnaires. Further modification of bacterial culture methods finally allowed the isolation of causative bacteria, now known as Legionella pneumophila.
Note: cancer is a form of tumor that can infiltrate other tissues, also known as malignant. Lipomas are defined as benign and rarely infiltrate other tissues. But cancers are still tumors as are lipomas. We can learn a lot from studies that research cancers eventhough lipomas aren't cancer.

He speaks also about the pleomorphic form of some bacteria. This means that bacteria may have virus like and fungus-like, as well as mycoplasma-like phase. Mycoplasma-like bacteria lack of the cell wall and are consired as a special case of bacteria.

The article is very interesting and I suggest everyone to read it.

I then wondered whether he knows anything about benign tumors and possible link to bacteria. So I emailed him.

And he replied:
HI Matt:

I never studied lipomas for bacteria.....although I found bacteria in inflammations of the fatty portion of the skin (panniculitis). Also there is some evidence that similar bacteria are found in "benign" diseases.

I honestly can't answer your question, but it wouldn't surprise me if bacteria were eventually found in connection with fat tumors. (emphasis added by Matt) I also think these bacteria, which we all carry, are implicated in many forms of disease.......perhaps one's genetic makeup determines how these bacteria eventually influence the cancerous and non-cancerous diseases that plague us all eventually.

We have much to learn.

Thanks for your interest.

Dr C
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Re: Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by matt » Fri Dec 30, 2011 8:45 am

After some more discussion with Dr. Cantwell, he was kind enough to direct me to a couple of studies which include somewhat benign tumors and bacterial findings.

The first is a Kaposi's sarcoma which according to Dr. Cantwell was a fairly benign tumor before the discovery of AIDS. It is a tumor caused by Human herpesvirus 8 (HHV8) and the cause was found in 1994 according to the Wikipedia. Kaposi's sarcoma is today very common among AIDS patients.

Dr. Cantwell's study was made in 1981 so it's long before they accepted that herpesvirus was the cause.

Still, it makes me wonder why Dr. Cantwell found many different bacteria from his skin tumor samples?

From different samples (cultures) he found:

Corynebacterium sp
Propionibacterium acnes
Staphylococcus epidermidis
Streptococcus viridans

In another study of Dr. Cantwell, he describes how he found also Staphylococcus epidermidis from the condition of Hypodermitis sclerodermiformis or Lipodermatosclerosis which is a benign skin and connective tissue disease. It's characterised as an inflammation of the layer of fat under the epidermis and pain is common.

Lipodermatosclerosis is classified as a form of lower extremity (legs) panniculitis (inflammation of subcutaneous adipose tissue or the fatty layer under the skin).

It is not known what causes the above condition but it is commonly diagnosed in middle-aged women.

I wonder if all these tumor and fat disorders have the same origin but they manifest themselves in various ways?

So what is lipoma? A body's response to an inflammation caused by a pleomorphic bacteria...?

Here's a 35 minute video where Dr. Cantwell speaks about this connection of bacteria and many kinds of associated illnesses. The main emphasis is on Russell bodies, cell organelles which Dr Cantwell says are actually microbes:


I recommend you watching also the second part of it mostly about AIDS and bacteria but there are some good information in this too (lenght: 40 mins):
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Re: Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by sjohn » Fri Dec 30, 2011 10:36 am

Great info, thanks Matt!
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Re: Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by matt » Wed Feb 29, 2012 2:02 pm

Every now and then the researchers announce they've found a "new" antineoplastic (antitumor or anticancer) substance. I thought I would start to list those here which are also known to be antimicrobial. There are quite a few of those.

Image

Below is a list of substances which are both antitumor and antimicrobial. I have collected these during the years (and the list is constantly growing):

Broccoli
Pine bark extract (Pycnegenol)
Grape seed extract
Turmeric
Noni juice
Sodium bicarbonate
Apricot seeds
Beta Glucan
Resveratrol
Polysaccharopeptide
Silibinin Extract From Milk Thistle
Ozone
Kombu Seaweed
Cannabis (THC)
Colloidal silver
Iodine
Selenium
Green tea
Flax oil
Apple (Phloretin)
Chickweed
Lemon
Vitamin C
Vitamin D
Tomato (Lycopene)
Aspirin (Acetylsalicylic acid)
Isothiocyanates (Cruciferous vegetables like cabbages, broccoli, cauliflower and turnip)
Hemp Seed Oil
Quercetin (fruits, vegetables, leaves and grains)
Capsaicin (chili peppers)
Electromagnetic fields
Oregano (Carvacrol)
Heparin
Honey (Bee)
Celery (Apigenin)
Parsley (Apigenin)
Garlic (ajoene, diallyl trisulfide)
Aloe vera
Spinach
Glycine
Indian Neem tree (Azadirachta indica) extract gedunin
Bitter melon (Momordica charantia)
Phenylacetic acid (one of the main compounds in the Burzynski protocol aka antineoplaston)
Propolis (collected by honey bees from tree buds and other botanical sources)
Omega-3 fatty acids
Hyaluronic acid
Lactic acid and salt
Citric acid and salt
Acetic acid and salt
Certain platinum, copper, gold and silver complexes
Essential oils (e.g. Cinnamon, Thyme, Eucalyptus, Oregano, Lavendar, Mint, Onion, Peppermint, etc)
Many mushrooms (Lingzhi (aka Reishi), Cordyceps (C. sinensis, C. militaris, C. pruinosa and C. ophioglossoides), Phellinus linteus, Coriolus versicolor, Shiitake)
Melatonin
Probiotics

What are the odds for this? :shock:

Ok, now I haven't placed links to the scientific evidence in the corresponding places but I assure you I have done the research (I'm planning to do this in some point). But for now you may test this yourself by going to http://scholar.google.fi and search with search terms like

spinach antitumor
lemon anticancer
iodine antibacteria
resveratrol antimicrobial
resveratrol antitumoric


And so on.

I'll add more when they come up.

I did a little slideshare presentation about this, perhaps you want to share it forward?

P.S. Most of these you can try on your own but if you want some more potent and readily extracted products you may find some of them from Amazon and/or IHerb.
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Re: Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by matt » Fri Mar 16, 2012 1:00 pm

Here's another interesting article by Dr. Cantwell:

The Russell Body: The Forgotten Clue To The Bacterial Cause Of Cancer

It tells about certain cell organelles - the Russell Bodies - and their possible role in cancer and other diseases. Dr. Cantwell believes most scientist do not notice these organelles - or as he says bacteria - in tumorous growths. The reason being that Russell bodies are pleomorphic bacteria resembling mycobacteria, known for it's special properties such as the lack of the cell wall.

The scientific world does know about Russell bodies but think differently about them than Dr. Cantwell. And after reading the article I find it possible there's a link between cancer and Russell bodies.

Maybe something similar is going on with lipomas (and other tumors) too.
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Re: Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by matt » Thu Apr 26, 2012 4:45 pm

I really enjoyed reading this: Is cancer just an incurable infectious disease?

It's an 11 paged hypothesis and easy to read with lot's of good info in it!

It says among other things that Dr. Livingston and Allen found that they could actually differentiate malignant from benign tissue by their mycobacterial content. Unfotunally when I tried to find the original study, it was nowhere to be found :( If someone finds it, please post it:

Code: Select all

Livingston V, Allen RM.
Presence of consistently recurringinvasive mycobacterial forms in tumor cells. Microscop Soc
Bull 1948;2:5–18.
The paper also includes that maybe the separation between malignant and benign tumors has become too sharp:
Smith had long suspected a bacterial cause for human cancer and criticized pathologists for drawing:

Too sharp a demarcation between malignant tumors, on the one hand, where the cells of the animal or human host, acting under some unknown stimulus are responsible for the tumerous growth and granulomata (benign tumors) on the other hand, such as tuberculosis and actinomycosis, where a visible microbe is responsible for the primary tumor, and the direct migration of this microbe for any secondary tumors that may appear. Rogers, 1952

Smith’s conclusion:

At the bottom, I think the distinction between such a disease, for example as tuberculosis or leprosy and malignant tumors is not as sharp as some histologists have been inclined to believe. Rogers, 1952
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Re: Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by matt » Fri Jul 13, 2012 12:47 pm

Here's an image from nature.com:
nbt0703-756-F1.jpg
Simplified model for oncolytic viruses
Oncolytic viruses are special viruses that can destroy tumors. Engineered properties include alterations in endogenous gene expression and introduction of foreign genes. The first oncolytic viruses were natural, like the reavirus which causes colds and mild stomach upset.

It says in the caption of the above image that
  • oncolytic viruses find their way into the supportive intracellular milieu that prevents free-flow of the produced viruses.
  • the host may have reexisting antibodies to the virion capsules thus decreasing the effective dose of the inoculum
  • the host has innate immunity protection against the viral infection
  • the host will mount a potent cellular and antibody response to the virus infection, potentially compromising follow-up treatments
  • tissue architecture may include fibrotic areas that prevent viral spread
  • tumor necrosis may also prevent viral spread
  • the immune response may generate tumor and normal cell death.
I find it somehow interesting there are so many similarities to lipomas in the process... Now what if the process that creates lipomas is actually caused by microbes?
  • Lipomas are often solitary lumps with little metabolism
  • Many treatments, like phosphatidylcholine, may initially work but slowly loses it's effect and lipoma will start to grow again
  • Lipomas often have fibrotic areas
  • Lipomas often have necrosis
Maybe some treatments initially work but lose their effect because the microbes adjust to the environment. Maybe the fibrotic tissue and necrosis is there to prevent microbes from spreading?

A connection between cancer and viruses has long been theorized, and case reports of tumor regression after immunization or infection with an unrelated virus have been documented. Infact viruses are still actively studied for cancer treatment. Today the scientists are trying to develop engineered viruses that are disregarded by the immune suppression.

Virus therapy seems to be working best when the viruses are injected directly into the tumor.

Scientists have also found that women who carried the AAV2 virus and human papillomavirus (HPV), which causes cervical cancer, had a lower propensity to develop cervical cancer. This is believed to be because of the co-existence of the AAV2 virus which is naturally occurring and carried by up to 80 percent of humans, but doesn't not cause any disease.

So AAV2 prevents HPV from causing cancer.

Certain viruses, like the reovirus, that causes colds and mild stomach upsets, prefer to attack cancer cells. They also stimulate the immune system to attack tumors.

The challenge is how to get the viruses into tumors without alerting the immune system to destroy them. One way is to inject them into the tumors, but this is technically difficult and particularly so for tumors that are deep inside the body, such as in the lungs, stomach, liver and pancreas. Lipomas instead are usually superficial and could easily be injected with oncolytic viruses.

One should also notice that the oncolytic viruses kill tumor cells but leave healthy cells alone.

But why would virus kill another? I believe it's all about survival of the fittest. It's already known that certain fungus can produce chemical which has antimicrobial effects. In s similar way two different viruses could battle about the living space. I think it's like mixing two species of ants together, those who are outnumbered will lose.
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Re: Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by matt » Mon Jul 16, 2012 9:37 am

In a book called Advances in Virus research originally published in 1966 the researchers describe in a chapter called Amphibia-related viruses that certain frog lipomas (and/or liposarcomas) have been associated with viruses. These frogs were Wisconsin frogs or Northern Leopard frogs (Rana pipiens).
northernleopardfrog2.jpg
Northern Leopard Frog
The researchers were stimulated by the cancer research efforts where they had just begun to see the virus-neoplasm connection.

The viral etiology of a frog lipoma is suspected on the basis of the cell-free filtrate transmission experiments. They found an adipose tissue tumor on one frog. Fragments of this tumor were implanted on into the anterior chamber of the eye of three similar frogs.

Two of these frogs developed a lipomatous tumor and multiple viscelar tumor foci while the third was apparently unaffected.

Since it's known that the cornea of the eye provides an effective barrier against metastasis, the assumption in the case of the two "takes" is that there is present a sub-cellular inducing agent, possibly a virus.
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Re: Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by matt » Sat Oct 06, 2012 9:25 pm

A refreshing and a very interesting study and hypothesis about pleomorphic bacteria and it's role in different diseases - tumors included. This one was published in 2010 so the subject is still relevant and not just some ancient chit chat.

What is ancient is the common opinion that microbes can't change their form. Scientists see microbes all the time in tumors but they think it's insignificant staining artifacts or debris. This dates back to the 19th century. The study hypothesizes that this opinion is wrong.
Although these forms have been observed in stained tissue histopathologic specimens for many decades, most are ignored and generally regarded as diagnostically insignificant staining artifacts or debris. It is hypothesized that these pleomorphic forms are not staining artifacts/cellular debris, but instead represent various stages in the life cycle of stressed bacteria: cell wall-deficient/defective (often called L-forms) that are difficult-to-culture or nonculturable.
Why are they saying this if everything about cancer and bacteria connection is already known:
Despite a voluminous literature on the subject and general non acceptance of the role of persisting forms (bacteria?) in cancerous tissues, the time may now be propitious to mobilize and utilize modern molecular microbiological technology to define the nature of pleomorphic bodies in a variety of cancers.
It looks like pleomorphic bacteria might still be the root cause for tumors but no scientist is willing to take the route to study and publish the findings in order to keep the respectation of the fellow scientists. Dr. Cantwell and some others have done it but they have all been ridiculed and supressed quickly. No wonder nobody wants to step up.

But it cannot go on like this forever.
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Re: Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by matt » Mon Oct 22, 2012 8:38 am

It is a well known fact that most cancers become resistant to a cancer drug - even to multiple drugs.

Have you ever wondered why? Why these abnormal cells would want to develop any sort of resistance?
Yes, they are living things but so are the normal cells which don't have the ability to become resistant.

The method of how cancer cells become resistant to chemo drugs is often explained by DNA mutations. Later, it has been proposed that the cells can actually become resistant even before any mutations occur.

Some scientists argue that a few cells may often become resistant before they get specific genetic mutations. Such non-genetic resistance may occur through the random variation in cellular characteristics that has been widely observed among genetically identical cells.

Alternatively, non-genetic resistance may occur when cells change (essentially reprogram) their characteristics in response to the stress of moving into new tissues, or dealing with toxic drugs.

Cells are known to have many flexible programs of expression in response to a change in their environment. If cells first become resistant by either non-genetic randomness or flexibility, then those resistant cells can later acquire genetic changes to stabilize their resistance.

P-glycoprotein or P-gp or the multidrug transporter is the protein thought to be the reason for the resistance. This protein shoots out any harmful substances out of the cell.

Did you know that bacteria have similar proteins that do the exact same? Bacteria can become resistant to multiple drugs via similar proteins.

Infact, this study demonstrates that bacterial LmrA (Lactococcus lactis protein responsible of antibiotic resistance) and human P-glycoprotein are functionally interchangeable and that this type of multidrug-resistance efflux pump is conserved from bacteria to man.

HMGIC (High mobility group protein isoform I-C) also known as HMGA2 or the high mobility glycoprotein is the protein often implicated in lipomas.

I think that somehow microbes might be interacting with cells, perhaps by entering them and using them as shields and modifing their properties by various ways to their benefit.

Like the study above stated it is likely that human cells have "inherited" many functions from bacteria, thus it would not come as a surprise if bacteria could still interact with human cells. In the end bacteria were the ones who engineered human cells. I believe bacteria preserve the right to continue engineering our cells but I think we shouldn't accept all kinds of engineering any longer.
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Re: Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by matt » Wed Oct 24, 2012 7:54 am

I believe that bacteria, virus and fungus are each other's pleomorphic forms. This means they are capable of transforming into each other. This is a very controversial subject but has persistently existed for decades.

Here is an example of how a diagnosed brain cancer tumor turned out to be a fungus infection. The patient was treated for fungal infection for months and his brain tumor like lesion was cured. Here's some more info about fungus and tumors.
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Re: Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by matt » Tue Mar 19, 2013 9:38 am

This study let's us know that bacteria can induce lipoma-like subcutaneous nodules in the fat tissue with fat necrosis.

The patient had several of these painless and itching subcutaneous nodules in his left thigh.

Mycobacterium ulcerans DNA was detected by using acid-fast staining. The histology of the nodule showed inflammated cheese-like fat tissue with moderate amounts of bacteria.

It was concluded that the patient had an infection of subcutaneous fat, Buluri ulcer, a condition caused by Mycobacteria ulcerans. The infection in most instances presents as a subcutaneous nodule, which is characteristically painless. The infection is mostly on the limbs, most often on exposed areas but not on the hands or feet. In children all areas may be involved, including the face or abdomen. Skin ulceration is a secondary event.

The Mycobacterium produces a toxin which causes fat necrosis and inhibits immune response.

An interesting side note is that the infection may frequently follow physical trauma, often minor trauma such as a small scratch.

Also interesting is that the patient in the study developed symptoms about a year after being in a Mycobacterium ulcerans infection area. Delayed onset of disease has been described and probably represents reactivation of latent infection. It has been observed that individuals can develop subcutaneous nodules at a body site where trauma occurred several years after the original Mycobacterium ulcerans infection.

Mycobacterium can be difficult to detect from the tissue sample and use of multiple different detection methods may be needed in order to make a diagnosis.

The only effective treatment is surgery.
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Re: Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by matt » Fri Apr 05, 2013 1:01 pm

There's a certain microRNA called miR-155 or MicroRNA-155 in tumor cells that has been discovered to be connected to tumor growth and inflammation.

microRNA is a small non-coding RNA molecule which regulates how genes express themselves.

The more miR-155 there is in tumor cells the more the growth of blood vessels is promoted as well as the tumor inflammation, and metastasis.

This has led scientist to study ways to suppress the expression of miR-155 in tumor cells.

Interestingly many bacteria/virus induce the overexpression of miR-155 as well [1, 2].

It has also been discovered that miR-155 deficient mice are more susceptible to bacterial infections than the ones whose miR-155 expression is normal [1].

This makes me to conclude that most likely the overexpression of miR-155 is somekind of a byproduct of a bacterial infection.

The malignant form of lipoma aka liposarcoma has overexpressed miR-155. [1] This is also true for the benign form of lipoma [1]. So the miR-155 is most likely overexpressed in your lipomas too :(

Recently, resveratrol, a natural polyphenol with antioxidant, anti-inflammatory, antimicrobial , and anticancer properties, currently at the stage of preclinical studies for human cancer prevention, has been shown to induce the expression of miR-663, a tumor-suppressor and anti-inflammatory microRNA, while downregulating miR-155 and miR-21. [1]
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Re: Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by matt » Sun Jan 11, 2015 8:08 pm

Bacteria could contribute to development of wound-induced skin cancer says this new study. What if bacteria play a role in lipomas as well? Perhaps some trigger is needed in order for the bacteria to start forming tumors, like a wound in the study? For lipomas the trigger could be an injury of somekind or hormonal or toxins or the food we consume...
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Re: Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by dannyg » Mon Jan 12, 2015 11:02 pm

Interesting. This reminds me that when I went to get my Lipoma's checked out when I didn't know what they were, the doctor noticed a small black pigmentation on one of my lipomas. He said that it's a sign of a bacteria infection. You can just barely see it through the skin, as if it's a tiny mole on the other side. It's on a lump that is roughly grape size and the black mark is like a spec or the size of a small seed. Bacteria infections seem to have horrible symptoms and look pretty nasty, where as I have no symptoms of a bacteria infection, so maybe my body formed a fatty lump to in-case it? Regardless, I do think bacteria plays a role in at least some of our Lipoma formations.
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Re: Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by dannyg » Wed Jan 14, 2015 1:40 am

Just noticed one of the Ayurvedic medicines (that worked on someone on this forum) called Gulguluthikthakam - fights bacteria! Here's the full description: "Various types of bacterial and fungal infections, eczema, candidacies, psoriasis, allergic dermatitis, sinusitis."

source
Curious

Re: Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by Curious » Thu Jan 15, 2015 5:00 am

Hi Matt,

Have you seen this recent study? And do you think that CAMP could somehow be related to lipoma formation?

http://health.ucsd.edu/news/releases/Pa ... ction.aspx
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Re: Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by 251152 » Sun Feb 01, 2015 11:53 am

dannyg wrote:Just noticed one of the Ayurvedic medicines (that worked on someone on this forum) called Gulguluthikthakam - fights bacteria! Here's the full description: "Various types of bacterial and fungal infections, eczema, candidacies, psoriasis, allergic dermatitis, sinusitis."

source
if you mean Vinay1122 from "Is This It? Triphala Ayurvedic Medicine As Lipoma Treatm" thread, he doesn't seem to write anything else besides his one post and then there's this shady "doctor" who's trying to build on what he said... it seems just like another scam
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Re: Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by dannyg » Tue Feb 03, 2015 12:33 am

I highly doubt it's a scam since both of them aren't advertising any specific products. We probably haven't heard of a lot of these Ayurvedic medicines since it's literally thousands of years old eastern medicines and a lot of them have different names, especially these days. Unfortunately, a lot of people aren't on this forum frequently, especially the people who have gotten rid of their lipomas - they tend to be nice enough to post what worked for them and then usually never come back, since there is no pressure for them to anymore. I don't know... let's just keep researching. ;)
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Re: Bacteria: The Ultimate Cause of Cancer (And Lipomas)?

Post by 251152 » Sun Feb 22, 2015 5:28 pm

Yeah I agree, it might seem like a scam because there are just so many scams around and people here are desperate, but it just logically doesn't make sense. If there's a substance that gets rid of lipomas (even if you have as many as he described) then how come so many Indians come to this forum in search for help? I'm sure that substance is pretty popular in India, and yet so many people come to lipomaboard?
I mean if it's credible enough for anyone here, why not give it a try? I personally am just tired of lying to myself
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