by Sparky » Thu Jun 14, 2012 10:58 am
1. Assuming a mutated chromosome case, I understand your thoughts with regards the secondary 'event' (I purposely tried to choose a word that wouldn't read too specific or descriptive).
2. With that in mind, and taking simplistically, mutation + trigger/event on = lipoma. Then as I see it, we either channel effort into fixing the mutation (impossibility / tall order?) and/or we somehow eliminate, mask, mute.... the trigger/event on (this could be singular or many). As you say, I'm sure you are correct in explaining the difficulty for us to understand precisely, down to the detailed level you describe, in making possible advances to a treatment. I'm also equally sure that you are correct in saying pathological analysis of lipoma is unlikely to find any answers down to this level. But, with the absence of this knowledge, what I'm proposing though, is that it is by understanding better the pathology and by identifying connected differences within standard adipose, that this would not only contribute specifically to the detailed research, but would also provide for a better informed path for the likes of us 'lumpys' to take at this time. It may well prove to be all 'in vain' but hey, you never know!
When's a lipoma a lipoma? (no, not the start of a joke!). I understand there is often confusion between, lipoma and cysts, boils or other malignent tumour types, but I think I'm right in saying 'Lipoma represents by far the most common mesenchymal neoplasm'. So, unlike your headache example, I do think that becuase lipoma are underpinned with some basic similarity (especially those that are common sucutaneous), that you can afford to view these similarly for possible treatements against those findings in the study article I pointed out. Actually, there are numerous similar 'lipoma' study’s that highlight these specific irregular enzyme activities. I'm not shouting 'euika', just that as a trend I want to know more.
Do you have any knowledge or views on the study findings and these particular enzymes? (you indicated you might a few posts back).
In the UK, there are 28 NHS regional DNA/genetic testing centres, I called up the UKGenetic Testing network that work with the NHS, and it seems I could get tested this way (I'd need to do this through my GP, but there's a chance I might not be worthy of them spending money on). There are also other private companies offering paid for services (mainly for paternity it seems though).
I'm not sure I have much more to 'tease' out from where we started with this discussion, but a big THANKS for your comments and thoughts!