2012 Glycine Patent

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Lurker

2012 Glycine Patent

Post by Lurker » Mon Oct 22, 2012 4:51 pm

I just came across this pending patent for a treatment that involves injecting glycine into the Lipoma.
Has anyone heard of this? Is this in a clinical trial anywhere?

Just thought I'd share... sorry if it is common knowledge or BS.

http://www.faqs.org/patents/app/20120122984
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matt
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Re: 2012 Glycine Patent

Post by matt » Tue Oct 23, 2012 7:33 am

Hi Lurker,

and thanks for the info! This is the first time I hear about glycine as a possible treatment. I know glycine is sold as sweetener and taste enhancer.

I googled some and found out that it does have some antitumor properties [1, 2].

And apparently an excess of glycine inhibits the growth of many bacteria, and it is used as a nonspecific antiseptic agent due to its low level of toxicity in animals [1, 2]. I guess I have to add glycine to my list of antitumor and antibacterial substances.

Interesting!

On the other hand I found out that glycine has also been associated with tumor growth. I hate it when there's always confusing information available...

Well, in the end there seems to be more studies and articles for the antitumor effects of glycine. Maybe the glycine was actually associated with the tumor growth since it was trying to slow down the growth and not to accelerate it? Who knows :roll:
Hi I'm Matt - the creator and owner of this site. I have dozens of small nasty lipomas all over. I've tried many treatments including surgery and Lipostabil injections. See my lipoma prevention supplement recommendations and please consider donating a small amount via PayPal (click the Donate button) to keep this site up and running. Thx!
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Re: 2012 Glycine Patent

Post by matt » Sun Sep 15, 2013 12:52 am

It's also interesting that they are suggesting topical and oral administration of glycine too in addition to injections and many other methods. I guess it's the way patents are written.
Lipomas and Liposarcomas

The invention provides methods of treatment of lipomas or liposarcomas. Lipoma types include, e.g., angiolipoma, angiolipoleiomyoma, neural fibrolipoma, chondroid lipoma, spindle-cell lipoma, pleomorphic lipoma, intradermal spindle cell lipoma, hibernoma, and superficial subcutaneous lipoma. Glycine and/or glycine analogs can be used to treat lipomas or liposarcomas at injectable concentrations of about 0.1, 0.2, 0.5, 0.75, 1.0, 2.0, 2.5, 5.0, 7.5, 10.0, or 15.0 mg/ml or more. Alternatively, glycine and/or glycine analogs can be used to treat lipomas or liposarcomas at concentrations of about 15.0, 10.0, 7.5, 5.0, 2.5, 2.0, 1.0, 0.75, 0.5, 0.2, 0.1 mg/ml or less or any range between 15 and 0.1 mg/ml. Glycine and glycine analogs can be present at a concentration of about 0.5 1, 2, 3, 4, 5, 10, 15% or more or any range between about 0.5% and about 15%. Neutral glycine can be present in a solution of water or any pharmaceutically acceptable carrier. Glycine and/or glycine analogs can be administered parenterally, e.g., percutaneously, subcutaneously, intravascularly (e.g., intravenously), intramuscularly, intraarterial, intracapsular, intraorbital, intracardiac, intradermal, intraperitoneally, transtracheal, subcuticular, subcapsular, subarachnoid, intraspinal, intrasternal, or intrathecaly injection or infusion, or topically or orally (as described above).

Glycine and/or glycine analogs can also be administered by direct injection into the lipoma or liposarcoma or injection into the area surrounding the lipoma or liposarcoma. Several divided dosages of glycine and/or glycine analogs, as well as staggered dosages, can be administered or the dose can be continuously infused, or can be a bolus injection or infusion. Furthermore, the dosages can be proportionally increased or decreased as indicated by the exigencies of the therapeutic or prophylactic situation. Treatment of a lipoma or liposarcoma means the reduction or elimination of the lipoma or liposarcoma.

Administration of glycine and/or glycine analogs can occur four, three, two, or one times a day. Administration can also occur four, three, two, or one time a week or three, two, or one time a month. Administration of can continue until the lipoma or liposarcoma shrinks 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% (by weight or volume), or until the lipoma or liposarcoma is eliminated.

Treatment of Lipoma or Liposarcoma in an Animal

Using known techniques (e.g., diagnosis by a medical professional), an animal (e.g., a human, dog, cat, horse, etc.) in need of treatment for lipoma or liposarcoma can be identified. A therapeutically effective amount of glycine and/or glycine analogs can be administered parenterally, e.g., percutaneously, subcutaneously, intravascularly (e.g., intravenously), intramuscularly, intraperitoneally or intrathecaly injection, by infusion techniques, orally, or by any other suitable administration method.

At intervals during the treatment regimen, the animal is monitored for signs and symptoms of lipoma or liposarcoma. After the treatment period has concluded, again using known techniques, the animal is found to have decreased signs and symptoms of lipoma or liposarcoma and/or to be no longer in need for treatment or reduced treatment for lipoma or liposarcoma. The lipoma or liposarcoma size is reduced by about 5. 10, 25, 50, 75, or 100% or any range between about 5% and 100%.
Image
Glycine is sold as pills and powder and is quite affordable... :shock:
Hi I'm Matt - the creator and owner of this site. I have dozens of small nasty lipomas all over. I've tried many treatments including surgery and Lipostabil injections. See my lipoma prevention supplement recommendations and please consider donating a small amount via PayPal (click the Donate button) to keep this site up and running. Thx!
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Re: 2012 Glycine Patent

Post by matt » Mon Oct 28, 2013 10:34 pm

It's interesting that this study from 2012 indicates that glycine is associated with tumor growth. It describes that rapidly profiliating cancer cells thrive when excess glycine is available although the reason why fast-growing cancer cells consume so much glycine is not yet clear.

Then we have a study from 2007 in which the scientists describe how treatment with glycine blocks tumor growth and artery formation in tumor, thus limiting it's growth.

There's also a study from 1999 in which inhibition of melanoma tumors via dietary glycine is described in mice. The study concludes that glycine may have anti-cancer properties. Interestingly the mechanism of growth inhibition was not via a direct action of glycine on cancer cell growth since glycine did not inhibit the proliferation of these cells in a test tube.

Therefore, the inhibition of tumor growth was probably not due to a direct effect of glycine to decrease the size of the tumor, and it is hypothesized that it works by inhibiting blood vessel formation which indirectly prevents the growth of the tumor.

So I guess that if glycine would work on lipomas it would do it by limiting the growth of blood vessels in them.
Hi I'm Matt - the creator and owner of this site. I have dozens of small nasty lipomas all over. I've tried many treatments including surgery and Lipostabil injections. See my lipoma prevention supplement recommendations and please consider donating a small amount via PayPal (click the Donate button) to keep this site up and running. Thx!
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Re: 2012 Glycine Patent

Post by Guest » Tue Oct 29, 2013 4:15 am

Has anyone on here tried Glycine? Anything to report on its affect?
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Re: 2012 Glycine Patent

Post by matt » Tue Oct 29, 2013 12:29 pm

I've been eating it 1000mg per day for around a month or so. No visible changes but I do think it'll help me to control the growth of my lipomas.
Hi I'm Matt - the creator and owner of this site. I have dozens of small nasty lipomas all over. I've tried many treatments including surgery and Lipostabil injections. See my lipoma prevention supplement recommendations and please consider donating a small amount via PayPal (click the Donate button) to keep this site up and running. Thx!
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Re: 2012 Glycine Patent

Post by bas1978 » Sun Oct 04, 2015 1:41 am

Hi Matt,

One month is a little short? You always try it for longer periods?

Why did you thing it didn't control the growth?

Regards
Bas


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