I responded to this thread earlier. I was diagnosed with Adiposis Dolorosa a year ago. Never had a lipoma until 12/2010, when some sort of sickness hit me.. I had previously had bladder cancer and was treated with BCG Immunotherapy (Bovine Tuberculosis Vaccine) 3-4 years prior to the reaction. I had also suffered from a spontaneous tonsillar hemorrhage which may or may not have been caused by Strep.
The lipomas occurred after a few years of heavy drinking, after some sort of reaction on 12/2010.. Heavy alcohol use, plus what felt like small herniations going off in my chest one night, a bunch of electrical shooting pains. I also caught a coxsackie virus a few weeks prior to this event??
At the time my only big changes in diet were I was eating lots of oysters... What is the connection?
Well, I did a genetic test and found out I was an H63D/H63D homozygote, these are some of the genes for Hemochromitosis, which causes iron toxicity. I started snooping.. Did you know the they call Hemochromitosis the "celtic curse", certain forms are very common in Ireland. Did you know in Herbt's 2007 study/survey on Dercum's disease that I think ~60% of those afflicted with Dercum's disease were of Irish/Scottish heritage?
The high iron probably contributed to the many bacterial and viral infections.
Those with the H63D/H63D mutation have much higher levels of serum iron saturation. Normal is like 35%, Mine is 66%
I think I may have contracted a vibrio bacterial infection from the oysters (they love iron!!), something caused subcutaneous hemhorraging.. which indirectly caused the Dercum's disease. I have hundreds of small lipomas on my chest/abdomen. It took 2 years, but that completely stopped growing and are almost not painful at all anymore.
Could the herniation of extremely iron loaded blood cause oxidative stress to the subcutaneous fat? Bruising often forms prior to lipoma formation:
The bruising is caused by hemosiderin. Hemosiderin may deposit in diseases associated with iron overload.
So, I think there is a link to the bruising and the lipoma formation. I think possible excess free iron in the blood and/or hemosiderin may be part of the picture. What would excess oxidative iron do to the lyphatic system? People with fatty livers and cirhossis often have iron overload.. and I believe there are some correlations between liver issues, alcohol and lipomatosis.. Maybe the alcohol excess also messed up some internal secretion from my pancreas or liver as well?
Excess iron will also mess with your pituitary, which messes with your testosterone and estrogen levels.. I found that I had secondary hypogadism from a pituitary dysfunction. Maybe I was suffering from an estrogen dominance? (I think I was)..
I only grew these lipoma for about a one year period.. had 6 of them excised and examined. Lipoma, I had two cultured for BCG TB, negative.
Maybe it is a combination, excess oxidative stress from iron? Estrogen dominance? (About 85% of those with Dercums are female and the males typically suffer from low Testosterone). Maybe it is a hypersensitivity reaction to a bacterial or viral infection.. or a combination of several of these factors.
This article really makes me think there is something to this.. maybe related the Dercum's and Hemochromitosis:
Hemosiderotic fibrohistiocytic lipomatous lesion: ten cases of a previously undescribed fatty lesion of the foot/ankle.